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CatalYm Demonstrates Clinical Efficacy and Tolerability in First-in- Human Phase 1 Trial for Visugromab and Nivolumab Combination

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Munich, Germany, September 10, 2022 – CatalYm, today presented data from its first-in- human GDFather-1 trial (GDF-15-neutralizing antibody-mediated human effector cell relocation) at the European Society for Medical Oncology (ESMO) Congress 2022 held in Paris, France. The clinical trial evaluated the GDF-15 neutralizing antibody visugromab (previously known as CTL-002), in combination with anti-PD-1 therapy nivolumab in advanced-stage solid tumor patients who had exhausted all previous lines of treatment and had relapsed on or were refractory to prior anti-PD-1/PD-L1 treatment. The data presented during today’s oral “Investigational Immunotherapy” session showed an excellent safety and tolerability profile as well as significant tumor regression at therapeutic doses and lasting response levels in a patient population with an otherwise poor prognosis.